Company Description
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Toxin Conjugate (BTC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radio Conjugates (BRC™) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology.
Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Cambridge, Massachusetts US.
Culture is key and all Bicycle employees actively embrace and role model our company values:
- We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients.
- We are Dedicated to our Mission. You can’t change the world if you don’t have determination.
- We are One Team. We only succeed when we work together.
Job Description
The Senior Scientist of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Senior Director, DMPK. They will be responsible for coordinating DMPK experiments, interpreting and presenting data to drug discovery project teams.
Key Responsibilities
- Co-ordinate experiments with CRO’s.
- Review, interpret and report data in support of drug discovery projects.
- Present data at multifunctional project teams.
- Work collaboratively with other core disciplines within a project team to support smooth and timely progression of compounds through the drug discovery cascade.
- Integrate data from multiple sources to inform the understanding of bicyclic peptide distribution, metabolism and excretion.
Qualifications
- BSc in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
- In depth understanding of DMPK science.
- Working knowledge of multiple DMPK/ADME assays including ability to trouble-shoot
- Good knowledge, obtained from hands-on experience, of interpreting LCMS data from in vitro and in vivo experiments
- Experience working on drug discovery and/or development projects as a DMPK representative
- Excellent organisation and communication skills, both written and oral, confident presenting data.
- Hands-on experience of PK data analysis software packages to conduct non-compartmental analysis.
- Hands-on experience in in vitro-in vivo extrapolation (IVIVE), PK/PD, and/or physiologically based pharmacokinetic (PBPK) modeling preferred.
- Experience working on radiopharmaceuticals or peptides would be an advantage.
- Experience using Dotmatics would be an advantage
Additional Information
- State-of-the-art campus environment with on campus restaurant and Montessori nursery
- Flexible working environment
- Competitive reward including annual company bonus
- Employee recognition schemes
- 28 days annual leave in addition to bank holidays + option to buy up to 5 additional days annually
- Employer contribution to pension (employee does not have to contribute)
- Life assurance cover 4x basic salary
- Private Medical Insurance, including optical and dental cover.
- Group income protection
- Employee assistance program
- Health Cash Plan
- Access to company subsidized gym membership.
- Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.
- Cycle to work scheme
Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.
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